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Aspirin Can Minimize Mortality In High-risk Prostate Cancer Patients

Many studies have been conducted to determine the connection between aspirin and the low-risk recurrence of prostate cancer in patients at high risk. Evidence gathered revealed reduced prostate-specific mortality among high-risk patients who had aspirin every day.

However, the exact mechanism by which aspirin prevented cancer cell development, progression, and metastasis was not understood.

During a 2014 study, the level of prostate-specific mortality in high-risk prostate cancer patients who used aspirin daily after diagnosis dropped significantly compared to those who used it before diagnosis. The same results have been demonstrated in many other studies to provide strong evidence of the aspirin effect.

The investigation included the age of the patient at diagnosis, tumor stage, Gleason score, primary treatment method, and so on to help create a stratified matrix to discern the outcomes.

Aspirin has anti-coagulation properties that help in blood thinning. In the study, it was used by patients as a precaution against stroke and cardiovascular disease before it was discovered to affect prostate cancer mortality.

It is speculated that the anti-coagulative properties of aspirin inhibit the activation of platelets, which then discourages the activities of cancer cells that rely on hijacking blood platelets and their molecular factors. The drug’s selective effect on high-risk prostate cancer is due to the molecular characteristics of cancer that spreads more rapidly and is often diagnosed at an advanced stage. Such cancer may have certain susceptibility to aspirin inhibition.

Aspirin is an inhibitor of cyclooxygenase enzyme 1 (COX-1). It can modify the action of the enzyme COX-2 that helps in the progression of prostate cancer. This causes anti-inflammatory effects which are beneficial since chronic intraprostatic inflammation is associated with high risk for advanced prostate cancer. Aspirin is also known to inhibit the function of platelets and the growth of prostate cancer cells.

Researchers are working on carrying out larger randomized studies to determine if daily aspirin use can help deter prostate cancer. If this is confirmed, many cancer patients are going to benefit from aspirin’s anti-cancer potential.

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